Administrative data

Purpose flag:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
No guideline or GLP compliance stated, but study well documented.

Data source

Reference
Reference Type:
publication
Title:
Pathology of fathead minnows (Pimephales promelas) exposed to chlorine dioxide and chlorite.
Author:
Yonkos LT, Fisher DJ, Wright DA and Kane AS
Year:
2000
Bibliographic source:
Marine Environmental Research, 50: 267-271

Materials and methods

GLP compliance:
no data

Test materials

Identity of test material same as for substance defined in section 1 (if not read-across):
yes
Test material identityopen allclose all
Identifier:
CAS number
Identity:
10049-04-4
Identifier:
EC number
Identity:
233-162-8
Identifier:
IUPAC name
Identity:
chlorous acid

Test organisms

Test organisms (species):
Pimephales promelas
Details on test organisms:
Age: adult

Study design

Test type:
flow-through
Total exposure duration:
12 h
Post exposure observation period:
14 days recovery period

Test conditions

Test temperature:
25°C
Nominal and measured concentrations:
0.13 and 0.19 mg/L

Results and discussion

Effect concentrations
Duration:
14 d
Basis for effect:
other: total recovery of gill epithelium
Details on results:
Gill epithelium was the primary large tissue affected by chlorine dioxide exposure. Treatment produced dose-dependent gill pathology including epithelial lifting, hypertrophy, hyperplasia, lamellar fusion and necrosis. Complete recovery, even in fish with severe hypertrophy and lamellar fusion, was achieved within 14 days.

Applicant's summary and conclusion